Gemcitabine and cytarabine are deoxycytidine (dC) analogue prodrugs used against solid tumors and blood cancers, but their activity is limited by several resistance mechanisms involving drug uptake, activation…
Gemcitabine and cytarabine are deoxycytidine (dC) analogue prodrugs used against solid tumors and blood cancers, but their activity is limited by several resistance mechanisms involving drug uptake, activation and metabolic inactivation. Cytidine deaminase (CDA) contributes to resistance by…
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